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Figure 5 | Biology Direct

Figure 5

From: Distinguishing HIV-1 drug resistance, accessory, and viral fitness mutations using conditional selection pressure analysis of treated versus untreated patient samples

Figure 5

Effects of mixing Treated and Untreated data on selection pressure calculation. We have mixed the Treated (1797 samples) with the Untreated (2628 samples) to assess the effects of a mixed data on selection pressure analysis. This mixing caused up to two-fold decreases in positively selected Ka/Ks values (compared with the Treated dataset), with shifts averaging of 32.7%. Out of the 24 positively selected codons in the Treated dataset, only two became negatively selected in the Mixture dataset. K a /K s values with a LOD < 2 in the Mixture dataset were plotted as empty triangles.

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Biology Direct

ISSN: 1745-6150

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