Figure 5

Growth pattern of a tumor treated with maximum tolerated dose at generation 45. Growth pattern of a tumor treated with maximum tolerated dose at generation 45. A represents chemoresistance (red resistant and green sensitive), B represents hyperglycolysis (red high glycolysis and green low), C shows acid resistance (red resistant to low pHe and green sensitive) and D shows quiescent cells (green) and proliferative (yellow). Despite being 10 times smaller than the original tumor, it is entirely composed of chemoresistant cells (red) and will not respond to therapy.