Fig. 2

Kinetics of H/D exchange followed by FTIR for wt-Aro (panel a, blue symbols) and the two polymorphic variants (namely R264H, panel b, and R264C, panel c, blue symbols). The kinetics in the presence of the substrate androstenedione (green symbols) and the inhibitor anastrozole (red symbols) are also reported. The solid lines correspond to the best double exponential fitting curves, whose parameters are reported in Table 1