Fig. 8

Overexpression of miR-146a-5p in microglial exosomes attenuates memory deficits induced by IH8w in mice. (a) The Barnes Maze experiment was conducted on days 50–53, representing training and spatial probe paths of mice in the five groups. (b) The number of escape tunnel crossings during the probe trial of Barnes Maze. (c-d) The average speed and total distance in the probe phase of Barnes Maze. Data are presented as mean ± SD (n = 4–8) and analyzed using one-way ANOVA with Dunnett’s post hoc test or Dunnett’s T3 post hoc test. *P < 0.05, **P < 0.01, and ***P < 0.001