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Fig. 5 | Biology Direct

Fig. 5

From: PHF5A regulates the expression of the DOCK5 variant to promote HNSCC progression through p38 MAPK activation

Fig. 5

PHF5A promotes the migration and invasion of HNSCC

(A) Cell scratch assays showed the migration of cancer cells after knockdown of PHF5A in JHU011 and Tu686 cells. (B) Transwell invasion assays showed that invasion was largely inhibited after knockdown of PHF5A in JHU011 and Tu686 cells. (C, D) Cell scratch assays (C) and Transwell invasion assays (D) demonstrated that migration and invasion were enhanced following overexpression of PHF5A in FaDu and MEER cells. (E) Representative images of macroscopic lung metastatic nodules were photographed, and the numbers of lung nodules were calculated in a metastasis mouse model (n = 4). ***: P < 0.001, **: P < 0.01. EV, empty vector group; OE, PHF5A overexpression group

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Biology Direct

ISSN: 1745-6150

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