Skip to main content
Fig. 4 | Biology Direct

Fig. 4

From: MAP7D3, a novel prognostic marker for triple-negative breast cancer, drives cell invasiveness and cancer-initiating cell properties to promote metastatic progression

Fig. 4

Inhibition of MAP7D3 expression suppresses TNBC primary tumor growth and lung metastatic capability in a mouse model. (A) Schematics of the orthotopic and lung colonization mouse model. (B) Tumor growth kinetics of tumor-bearing mice. **P < 0.001. (C) Tumor weight analysis of tumors resected from the orthotopic mouse model. **P < 0.001. (D) The representative images of mouse lungs resected from the lung colonization model. White arrows indicated the metastatic lung nodules. (E) The representative HE staining images of mouse lung section from mice injected with the control cells and shMAP7D3 cells, respectively. M35etastatic tumors were indicated by the uppercase T. Scale bar, 50 μm. (F) The quantitative results of lung metastasis. Lung metastasis index was calculated as follows: lung parenchyma area that was taken up by metastatic tumors divided by the total area of lung parenchyma. **P < 0.001, *P < 0.05

Back to article page

Biology Direct

ISSN: 1745-6150

Contact us