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Fig. 5 | Biology Direct

Fig. 5

From: RCC2 promotes prostate cancer cell proliferation and migration through Hh/GLI1 signaling pathway and cancer stem-like cells

Fig. 5

RCC2 promotes cell propagation and migration through GLI1 in vitro. A The protein level of RCC2 and Gli1 in DU145 and PC3 cells transfected with Ctrl, RCC2, RCC2 + siGli1, and RCC2 + GANT61, respectively. B CCK-8 assay of cell viability in DU145 and PC3 cells between four groups. C Cell colony generation assay in DU145 and PC3 cells between four groups. D Cell migration ability in DU145 and PC3 cells between four groups. E Cell invasion assay in DU145 and PC3 cells between four groups. F The expression of CSC marker genes, including SOX2, Nanog, CD44. *P < 0.05, **P < 0.01, ***P < 0.001. G. The effect of RCC2 overexpression or knock down on the capacity of oncosphere formation. Representative images. Scale bar, 100 μm

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