Fig. 3

The correlation between circ_MAPK9 expression and HCC patients’ survival. A, The effect of circ_MAPK9 knockdown on tumor growth in vivo. Representative images of tumors formed in nude mice by subcutaneous injection of circ_MAPK9-silenced SMMC-7721 cells. B-C, The weight and volume of xenograft tumors displayed as mean ± SD in scramble and circ_MAPK9-silenced groups. D, The expression level of circ_MAPK9 in human liver cancer and paired adjacent normal tissues. E-F, Kaplan-Meier analysis of OS and DFS rate in HCC patients based on circ_MAPK9 expression level (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.001 vs. scramble group)