Fig. 1

Establishment of Cetuximab resistant cell line LIM1215-R and analysis of differentially expressed RNAs. A-B. Sensitivity of LIM1215 and LIM1215-R to Cetuximab: (A) Cell viability of LIM1215 and LIM1215-R treated with different concentrations of Cetuximab. (B) Clonogenic assay (Cetuximab 5 µg/mL). C-E. Heatmaps and volcano plots of differentially expressed RNAs between LIM1215 and LIM1215-R (fold change > 2, P < 0.05): (C) circRNA expression differences; (D) mRNA expression differences; (E) miRNA expression differences. ***P < 0.001