Fig. 5

Silencing of SFMBT2 promoted the migration, invasion and metastasis of clear cell RCC cells. A, B The migratory ability of 786-O and 769-P cells was evaluated by wound healing assay (the scale bar presented 200 μm). C, D The invasion of cells were assessed by transwell assay with matrigel supplementary (the scale bar presented 100 μm). E The GFP-stably-expressed 786-O cells were intravenously injected into nude mice, and the in vivo bioluminescence imaging was done. F, G The lung was isolated from mice, and the nodule numbers in lung were counted. H The pathological features of lung from 786-O cell-inoculated mice were detected by HE staining (the scale bar presented 50 μm). *p < 0.05; **p < 0.01; ***p < 0.001 versus LV-shNC