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Fig. 4 | Biology Direct

Fig. 4

From: YY1 mediated DCUN1D5 transcriptional activation promotes triple-negative breast cancer progression by targeting FN1/PI3K/AKT pathway

Fig. 4

DCUN1D5 promotes TNBC tumor growth and metastasis in vivo. A Images of xenograft tumors from groups of BALB/c-nude mice 25 days after the subcutaneous injection of stable DCUN1D5 knockdown MDA-MB-231 cells (shDCUN1D5) or control cells (shCtrl). B Tumor volume was calculated according to the formula: (length × width2)/2 every 3 days 1 week after injection. C Tumor weight in nude mice of shDCUN1D5 and shCtrl group was measured at day 25. D Hematoxylin and eosin (HE) staining and immunohistochemistry for DCUN1D5 and Ki67 in xenograft tumors (×200). Scale bar: 50 μm. E Representative images of tumor metastasis in lung tissues and the number of metastatic nodules in shDCUN1D5 or shCtrl group. The black arrows indicate pulmonary metastatic nodules (×40). Scale bar: 250 μm. ** p < 0.01, *** p < 0.001

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