Fig. 4

Molecular and chromosomal alterations detected in the breast cancer patient. Schematic structural features of A EGFR, B IGF1R, and D p53 proteins as well as mutations observed in the METABRIC and TCGA datasets. The mutations observed in both the METABRIC and TCGA-BRCA datasets and in the patient of this case study are highlighted with lollipop plots and were exported from cBioPortal. Patient’s mutations are indicated by an arrow. Data were obtained from cBioPortal. C, E IGF1R and CHD2 gene amplifications in the patient relatively to the clinical cohort. F CHD2, EGFR, IGF1R, and TP53 genomic alterations in the METABRIC and TCGA-BRCA datasets as an OncoPrint plot. The plots were exported from cBioPortal