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Fig. 4 | Biology Direct

Fig. 4

From: Hypoxia-induced activation of HIF-1alpha/IL-1beta axis in microglia promotes glioma progression via NF-κB-mediated upregulation of heparanase expression

Fig. 4

IL-1β from hypoxic microglia promotes glioma progression and causes activation of NF-κB and upregulation of HPSE in vivo. (A and B) Changes in tumor volume and weight were shown. (C) Relative protein levels of p-p65, p65, and HPSE, as quantified using western blot. (D) The histological morphology of tumor tissue was detected by HE staining. Relative protein levels of PCNA, E-cadherin, and vimentin, as quantified using IHC. n = 5. *P < 0.05, **P < 0.01,***P < 0.001

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