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Fig. 7 | Biology Direct

Fig. 7

From: C-MYC-activated lncRNA SNHG20 accelerates the proliferation of diffuse large B cell lymphoma via USP14-mediated deubiquitination of β-catenin

Fig. 7

SNHG20-facilitated DLBCL cell proliferation and apoptosis resistance are attenuated by β-catenin knockdown. (A) U2932 and OCI-LY3 cells were transduced with the corresponding vectors and subjected to WB for measurement of β-catenin and c-MYC levels. (B) The viability of DLBCL cells transduced with the corresponding vectors was evaluated by using a CCK-8 assay. (C) The proliferation of DLBCL cells transduced with the corresponding vectors was examined by using an EdU incorporation assay. (D) Differences in apoptosis were evaluated using flow cytometry in DLBCL cells transduced with the corresponding vectors after 24 h of DOX treatment. (E) OCI-LY3 cells transduced with the corresponding vectors were subcutaneously injected into nude mice. Tumour volumes were compared to detect differences in tumour growth. (F) Schematic representation of the findings of the current study. *P < 0.05

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