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Fig. 2 | Biology Direct

Fig. 2

From: Silencing LINC00987 ameliorates adriamycin resistance of acute myeloid leukemia via miR-4458/HMGA2 axis

Fig. 2

Decreased expression of LINC00987 reduces the cell viability and ADR-resistance of AML cells. (A) LINC00987 expression in ADR/MOLM13 and ADR/HL-60 cells was measured via RT-qPCR after siRNA transfection at 24 h. (B) The proliferation of ADR/MOLM13 and ADR/HL-60 cells was detected by CCK8 after siRNA transfection at 24 h under 0.2 µM ADR treatment. The cell viability was calculated according to proliferation. (C) Clone formation of ADR/MOLM13 and ADR/HL-60 cells was detected by soft agar colony formation assay. The number of cell clone formations was counted by imaging at 100x magnification. (D) Xenograft tumor was used to analyze the effect of LINC00987-silenced on the size of tumor growth. And LINC00987 expression in Xenograft tumor was measured via RT-qPCR. *P < 0.005 and ***P < 0.001

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