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Fig. 8 | Biology Direct

Fig. 8

From: YTHDC1 aggravates high glucose-induced retinal vascular endothelial cell injury via m6A modification of CDK6

Fig. 8

Overexpression of CDK6 reversed the protective effect of sh-YTHDC1 on diabetic retinopathy in rats. RT-qPCR analysis was used to detect the mRNA expressions of Ythdc1(A) and Cdk6(B) in retinal tissues. (C) western blot was performed to detect the protein expressions of YTHDC1 and CDK6 in retinal tissues. (D) The representative H&E stained images and quantitative analysis plots. (E) Periodic Acid-Schiff staining was used to detect the morphological changes of retinal capillaries. *P < 0.05, **P < 0.01, ***P < 0.001, vs. sham + AAV-NC group; #P < 0.05, ##P < 0.01, vs. STZ + AAV-NC group; &P < 0.05, vs. STZ + AAV-sh-YTHDC1 group, n = 6

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