Skip to main content
Fig. 11 | Biology Direct

Fig. 11

From: Epigenetic mechanism of RBM15 in affecting cisplatin resistance in laryngeal carcinoma cells by regulating ferroptosis

Fig. 11

Epigenetic mechanism of RBM15 in affecting cisplatin resistance in laryngeal carcinoma cells by regulating ferroptosis. RBM15 regulated the stability of KDM5B in an IGF2BP3-dependent manner, promoting the expression of KDM5B. KDM5B downregulated FER1L4 through demethylation of H3K4me3 and H3K27me3 while upregulated KCNQ1OT1. FER1L4 and KCNQ1OT1, respectively, bounded to MYC, inhibiting the expression of GPX4 and ACSL4. RBM15 promoted DDP resistance in LC cells by inhibiting ferroptosis

Back to article page

Biology Direct

ISSN: 1745-6150

Contact us