Fig. 6

Effect of CNBP and LINC00665 on ovarian cancer tumor growth in vivoA. Tumor-bearing nude mice and tumor samples from each group. B. Tumor volume was calculated every three days after injection. All tumors were excised four weeks after injection, and the tumor growth curve of CNBP-overexpressing OCSCs was compared with that of the control group. C. Comparison of tumor growth curves of OCSCs with LINC00665 inhibition alone or OCSCs with co-suppression of LINC00665 and CNBP expression with that of the control group. D. Expression of stemness marker proteins, proteins related to cell biological behaviors, and pathway proteins detected by western blotting. E. Disease-free survival analysis of ovarian cancer samples. The survival time of patients after surgery was compared between high-CNBP and low-CNBP expression groups. F. ChIP assay showing endogenous NFYA bound to the LINC00665 promoter in COC1 cells. G. LINC00665 increases CNBP degradation in OCSC via the SMD pathway to participate in OCSC stemness regulation, *P < 0.05