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Fig. 2 | Biology Direct

Fig. 2

From: METTL3 in cancer-associated fibroblasts-derived exosomes promotes the proliferation and metastasis and suppresses ferroptosis in colorectal cancer by eliciting ACSL3 m6A modification

Fig. 2

CAFs suppresses CRC cell ferroptosis. (A-D) LoVo and HCT-116 cells were treated with 40​ µM DMSO or Erastin for 24 h, followed by NF-CM or CAF-CM incubation in Erastin-treated cells for 48 h. (A) MTT assay for cell viability. (B-D) The accumulation of ROS and Fe2+, and the exhaustion of GSH were detected using commercial kits. Technical replicates (n = 3), biological replicates (n = 3), *P < 0.05

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