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Fig. 8 | Biology Direct

Fig. 8

From: METTL3 in cancer-associated fibroblasts-derived exosomes promotes the proliferation and metastasis and suppresses ferroptosis in colorectal cancer by eliciting ACSL3 m6A modification

Fig. 8

Knockdown of METTL3 in CAFs-exo impedes CRC growth and metastasis by regulating ACSL3. (A, B) The growth curve of tumors (A), the representative tumors and the weight of xenograft tumors (B). (C, D) Measurement of METTL3, ACSL3, PCNA, and MMP9 protein levels in xenograft tumors in each group. (E) IHC analysis for METTL3, ACSL3, PCNA, and MMP9 positive cells in tumors of each group. (F) The number of metastatic nodules in the lung of each group. (G) Representative H&E staining of lung sections. Technical replicates (n = 3), biological replicates (n = 5), *P < 0.05

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Biology Direct

ISSN: 1745-6150

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