Fig. 6

C-Myc was required for ADAMTS4-promoted tumor growth of lung cancer cells in mice. A The ADAMTS4-overexpressing lentivirus and c-Myc-silencing A549 cells were respectively or simultaneously injected into flanks of BALB/c nude mice. 7 days later, the tumor sizes were monitored once every 6 days, and the tumor volumes were calculated. (n = 4 mice per group). B After 31 days, all tumor tissues isolated from mice as well as the mice were photographed, and C tumor weight was quantified. (n = 4 mice per group). D The expression levels of Ki-67 protein in tumors of indicated groups were detected by IHC staining. (n = 4 mice per group). Results were presented as mean ± SD. **p < 0.01, ***p < 0.001