Fig. 6

Both hsa_circ_0020093 and LRPPRC regulates YAP activity. A Western blot analysis of P-YAP and YAP expression in LRPPRC-silencing and control OC cells. B Western blot analysis of P-YAP and YAP expression in hsa_circ_0020093-overexpressing and control OC cells. C RT-qPCR analysis of the expression of YAP-targeted mRNAs in LRPPRC-silencing and control SKOV3 cells. D RT-qPCR analysis of the expression YAP-targeted mRNAs in hsa_circ_0020093-overexpressing and control SKOV3 cells. E P-YAP and YAP protein level in xenograft tumors formed by control or hsa_circ_0020093 stably overexpressed SKOV3 cells were manifested by IHC staining. Scale Bar: 100 μm. F The IHC score of P-YAP and YAP in xenograft tumors formed by control or hsa_circ_0020093 stably overexpressed SKOV3 cells. P values were calculated by two-tailed Student’s t-test. ns: not significant; *P < 0.05; **P < 0.01; ***P < 0.001