Fig. 5

SAMHD1 regulates PTEN activity to influence the activation of the PI3K/AKT signaling pathway Note (A) Western blot detection of the effect of overexpressed SAMHD1 on PTEN expression; (B) IP to detect the interaction between SAMHD1 and PTEN; (C) Western blot detection of the inhibitory effect of overexpressed SAMHD1 on the PI3K/AKT signaling pathway of PTEN. Purple * indicates a significant difference compared to the oe-NC group or sh-NC + oe-NC group, with p < 0.05. Blue * indicates a significant difference compared to the sh-SAMHD1 + oe-NC group, with p < 0.05.(The data are presented as mean ± standard deviation, and an independent sample t-test was used for statistical analysis. The experiment was repeated 3 times.)