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Fig. 3 | Biology Direct

Fig. 3

From: Glucose deprivation-induced disulfidptosis in human nucleus pulposus cells: a novel pathological mechanism of intervertebral disc degeneration

Fig. 3

High expression of disulfidptosis signaling in chondrocyte subset in the IVDD group. A Processing of single-cell RNA-seq data from normal and degenerating nucleus pulposus tissues. B Original single cell t-Distributed Stochastic Neighbor Embedding (t-SNE) distribution map. C Cell markers annotation and cell subsets definition. D Three types of cell subsets t-SNE distribution map. E Differential expression of disulfidptosis signaling in three cell subsets and two groups. F Differential expression of disulfidptosis related genes in cell subsets. G Cell proportion with high and low ACTB expression in chondrocytes in normal and IVDD groups. H Cell proportion with high and low CAPZB expression in chondrocytes in normal and IVDD groups. I Functional enrichment in high and low ACTB expression groups in chondrocytes. J Cell proportion with high and low SLC7A11 expression in chondrocytes in normal and IVDD groups. K. Cell proportion with high and low GCLM expression in chondrocytes in normal and IVDD groups. L. Functional enrichment in high and low SLC7A11 expression groups in chondrocytes

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