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Fig. 7 | Biology Direct

Fig. 7

From: Glucose deprivation-induced disulfidptosis in human nucleus pulposus cells: a novel pathological mechanism of intervertebral disc degeneration

Fig. 7

Glucose starvation induced disulfidptosis in HNPC cells. A.HNPC cells died after glucose deprivation for 4 h. B. Known cell death inhibitors Z-VAD, Nec-1s, Liprox-1 and CQ cannot rescue cell death induced by glucose deprivation. C. Alterations in SLC7A11 expression levels upon glucose starvation. D. Reducing and non-reducing Western blotting analysis of actin cytoskeleton proteins in HNPC cells upon glucose deprivation. E. 2-DG saved glucose starvation-induced disulfidptosis in HNPC cells. F. NADP+/NADPH ratio was upregulated upon glucose starvation, and was rescued by 2-DG treatment. G. 2-DG alleviated the disulfide stress in HNPC cells upon glucose starvation

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