Regulating ferroptosis by non-coding RNAs in hepatocellular carcinoma

Biology Direct

Table 1 The regulatory role of miRNAs in modulation of ferroptosis in HCC

miRNA	Expression/function	Targets	Effects on tumour	Refs.
miR-214-3p	ND/Tumor suppressor	ATF4	Induce ferroptosis and inhibit HCC	[115]
miR-23a-3p	↑/Oncogene	ACSL4	miR-23a-3p suppresses sorafenib-induced ferroptosis	[116]
miR-552-5p	↑/Oncogene	ACSL4	Overexpression of ZNF8 reduces intracellular miR-552-5p levels and enhances sensitivity to ferroptosis. miR-552-5p inhibits ferroptosis by suppressing ACSL4	[117]
miR-142-3p	↑/Oncogene	FTH1, TfR1, GPX4, ATF4	Exosomal miR-142-3p from HBV-positive liver cancer cell promotes the progression of liver cancer by inducing ferroptosis of M1-type macrophages inhibiting SLC3A2	[118]
miR-142-3p	↑/Oncogene	SLC3A2	↑HBV-infected M1-type macrophage ferroptosis through inhibiting SLC3A2;↑ development of HCC	[119]
miR-21-5p	↑/Oncogene	MELK	miR-21-5p inhibits the ferroptosis through activating AKT/mTOR signaling pathway via upregulating level of MELK	[120]
miR-654-5p	-/Tumor suppressor	HSPB1	miR-654-5p alleviate sorafenib resistance through inducing ferroptosis by targeting HSPB1	[121]
miR-612	-/Tumor suppressor	CoQ10	miR-612 inhibit tumour malignancy through inducing ferroptosis by decreasing CoQ10 and increasing cellular PUFA levels via the HADHA-mediated MVA pathway	[122]
MiR-339-5p	↑/Oncogene	FTH1	miR-339 inhibits ferroptosis through suppressing ATG7-mediated autophagic degradation of FTH1	[123]
miR-4489	-/Tumor suppressor	MUC1	APOM suppress tumor and induces ferroptosis through down-regulating ferroptosis-inhibiting gene MUC1 via upregulating miR-4489	[124]

ISSN: 1745-6150