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Fig. 1 | Biology Direct

Fig. 1

From: METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10 expression and improve brain ischemia/reperfusion injury through YTHDC1

Fig. 1

Elevated lncRNA CRNDE levels in MCAO rats. (A) Behavioral assessment using the Morris water maze. (B) Neurological function score. (C) TTC staining for brain infarction evaluation. (D) Assessment of brain water content. (E) HE staining for observation of MCAO-induced injury. (F) TUNEL assay to detect cell apoptosis. (G) Measurement of lncRNA CRNDE expression levels. (H) qRT-PCR analysis of ATG10, LC3, Beclin1, and p62 mRNA. (I) Western blot analysis of ATG10, LC3II/I, Beclin1, and p62 protein levels. (J) Correlation analysis between lncRNA CRNDE and ATG10, LC3, Beclin1, and p62. *P < 0.05 indicates a significant difference compared to the Sham group. Data are expressed as Mean ± SD. Comparisons between two groups were performed using the unpaired Student’s t-test, and Pearson correlation was used for correlation analysis

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