Skip to main content
Fig. 2 | Biology Direct

Fig. 2

From: METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10 expression and improve brain ischemia/reperfusion injury through YTHDC1

Fig. 2

Effect of silencing lncRNA CRNDE on apoptosis and autophagy in OGD/R-induced SH-SY5Y cells. (A) Expression levels of lncRNA CRNDE in cells. (B) Flow cytometry analysis of apoptosis rate. (C) Protein expression of Bcl-2, Bax, and Caspase-3. (D) Measurement of inflammatory factor levels. (E) Expression of autophagy-related markers ATG10, LC3, Beclin1, and p62. (F) Quantification of ATG10, LC3II/I, Beclin1, and p62 protein levels. *P < 0.05 indicates a significant difference compared to the Control group. #P < 0.05 indicates a significant difference compared to the sh-NC group. Data are presented as Mean ± SD. One-way ANOVA followed by Tukey’s post-hoc test was used for comparisons among multiple groups

Back to article page

Biology Direct

ISSN: 1745-6150

Contact us