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Fig. 3 | Biology Direct

Fig. 3

From: METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10 expression and improve brain ischemia/reperfusion injury through YTHDC1

Fig. 3

Inhibiting lncRNA CRNDE suppresses further damage to brain tissues and promotes autophagy. (A) Rat swimming speed, latency time, and time spent on the platform in the Morris water maze. (B) Neurological function score. (C) TTC staining for evaluation of cerebral infarction area. (D) Assessment of brain water content. (E) HE staining for visualization of MCAO-induced injury. (F) TUNEL assay for detecting apoptosis. (G) Expression levels of lncRNA CRNDE in brain injury tissues. (H) mRNA levels of autophagy-related markers ATG10, LC3, Beclin1, and p62. (I) Protein levels of autophagy-related markers ATG10, LC3II/I, Beclin1, and p62. (J) Autophagy in brain tissues (red and yellow arrows indicate pyroptotic bodies). *P < 0.05 indicates a significant difference compared to the sh-NC group. Data are expressed as Mean ± SD. Comparisons between two groups were performed using the unpaired Student’s t-test

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Biology Direct

ISSN: 1745-6150

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