Table 5 Various intermolecular interactions of prioritized lead candidates and control molecule towards MurM

1.

CNP0056520

Ile313,

Leu314

2.39,

2.85

Trp31,

Ala316

4.77,

5.37

Leu26, Lys35, Gln153,

Pro154, Tyr219, Glu312,

Tyr315, Trp332, Met349,

Gly 350, Gly 351, Leu 360

2.

CNP0126952

Leu314

2.73

Leu26

Tyr315

4.01,

4.59, 5.30

Trp31, Lys35, Leu214, Tyr219, Ile313, Ala316, Trp332, Met349, Gly350, Gly351,Lys360, Lys364

3.

CNP0248480

Gly351

2.98

Leu214

Tyr315

Ala316

Trp332

4.79

4.67

3.53

4.79

Trp31, Met148, Gln153, Pro154, Ile212, Ser213,

Glu312, Ile313, Leu314,

Met349, Glu350, Leu360, Lys364

4.

Control

(Deoxyribofuranosephosphonate)

Asn37,

Lys60

2.76,

3.07

Lys35,

Trp38

4.28,

4.56

Pro61,Arg215,Tyr219