Fig. 5

AD-associated differentially abundant genome bins at family, order, and class taxonomic ranks. The figure depicts the differentially abundant genome bins identified from two assessments: differential abundance in AD relative to control samples at each sampled time point, and differential abundance between pairs of time points (2, 6, and 12 mos) in AD samples. The heatmaps arranged from left to right display the outcomes of these differential abundance tests at the family, order, and class level, respectively. In each heatmap, column labels outline the conditions compared. The tests for differential abundance in AD samples between pairs of time points are labeled as AD.2M.vs.12M, AD.2M.vs.6M, and AD.6M.vs.12M. Time-wise differential abundance tests are labeled as 2M.AD.vs.WT, 6M.AD.vs.WT, and 12M.AD.vs.WT. Row labels indicate the taxa that were found to be differentially abundant in at least one test. Changes in relative abundance are expressed as log₂FC. Color coding represents the intensity in fold change, with grey indicating genome bins that did not show statistically significant variations in relative abundance under the compared conditions. A genome bin is deemed differentially abundant between two conditions if it features |log₂FC| > 1 and a Benjamini-Hochberg’s adjusted p-value < 0.05