Fig. 6

Time-associated differentially abundant SGBs. The figure shows the species genome bins that were identified as differentially abundant when comparing microbiome profiles between pairs of sampled time points (2, 6, and 12 mos) in AD samples. Differential abundance tests carried out in AD samples at T1 = 2M relative to T2 = 6M, at T1 = 2M relative to T3 = 12M, and at T2 = 6M relative to T3 = 12M are referred to as AD.2M.vs.12M, AD.2M.vs.6M, and AD.6M.vs.12M in the heatmap column labels. Row labels report the SGBs deemed differentially abundant over time. The vast majority of these SGBs do not align with any reference genome. The annotations on the left side of the heatmap categorize the differentially abundant SGBs by phylum, class, order, and family. Changes in relative abundance are reported as log2FC. Color coding indicates the intensity in fold change. Cells colored grey in the heatmap represent genome bins that did not show statistically significant changes in relative abundance between the tested temporal points. SGBs are deemed differentially abundant between two conditions if they feature a |log₂FC| > 1 and a Benjamini-Hochberg’s adjusted p-value < 0.05