Fig. 1
From: Disulfidptosis-related subtype and prognostic signature in prostate cancer
Connection between disulfidptosis-related genes and prostate cancer: a Mutation status of DRGs in the TCGA-PRAD cohort. b Chromosomal positions of DRGs. c Copy number variations of DRGs, with green balls indicating that "loss" is more frequent than "gain" in DRGs, and vice versa. d Differential DRGs between normal tissue and tumour tissue in the TCGA-PRAD cohort. e Impact of SLC7A11 on PFS. f, g qPCR and WB results of SLC7A11 in PC-3, DU-145, and RWPE-1 cells. h Results of single-cell sequencing of prostate cancer cells in the GSE141445 dataset and UMAP dimensionality reduction analysis of the distributions of various immune cells and malignant cells. i SLC7A11 expression in different prostate cancer cell subsets. j, k qPCR and WB were used to verify the plasmid transfection efficiency of SLC7A11 in DU145 and PC3 cells. l, n A scratch assay confirmed that SLC7A11 promoted the migration of DU145 and PC3 cells. m, o Transwell assays confirmed the role of SLC7A11 in promoting the invasion of DU145 and PC3 cells (triplicates). p, q IC50 values of BAY-876 in PC-3 and DU145 cells. r Inhibitory ability of BAY-876 on PC-3 cells in the SLC7A11-OE, SLC7A11-EV, and control groups. s Inhibitory ability of BAY-876 on DU145 cells in the SLC7A11-OE, SLC7A11-EV, and control groups