Fig. 1

Expression patterns of m6A regulators in HCC. A, Differences in m6A regulator expression between HCC and non-tumor samples across 20 datasets. B, Differences in m6A regulator expression in GSE14520 − GPL3921. C–D, Expression differences of METTL4 and CBLL1 in GSE14520 − GPL3921. E–F, METTL4 and CBLL1 proteins expression in the human protein atlas. G, Analysis of m6A regulators expression in different cells using the single-cell sequencing gene dataset GSE202642. H, Single-cell sequencing analysis of IGF2BP2 expression in various cells. Down, under-expressed in HCC tissues; Up, over-expressed in HCC tissues. eraser, demethylase; reader, m6A binding protein; writer, methyltransferase. Exp, normalized gene expression value. TEC, tumor-associated endothelial cells. CAF, cancer-associated fibroblasts. TAM, tumor-associated macrophages. HPC-like, cells with an unknown entity but express hepatic progenitor cell markers. *P < 0.05, ***P < 0.001