Fig. 2

Genetic features of m6A regulators in HCC. A, CNV features of m6A regulators in TCGA. B, Differences in seg.mean of m6A regulator between HCC and non-tumor samples. C–D, Seg.mean of IGF2BP3 and IGF2BP2 in HCC and non-tumor samples. E, Relationship between CNV and gene expression of m6A regulators. F–G, Relationship between CNV and gene expression of ALKBH5 and KIAA1429. H, Differences in DNA methylation of m6A regulator between HCC and non-tumor samples. I–J, DNA methylation of ALKBH5 and ALKBH3 in HCC and non-tumor samples. K, Relationship between DNA methylation and gene expression of m6A regulators. L, R Association between DNA methylation and gene expression of ALKBH3. M, SNP features of m6A regulators in TCGA. Seg.mean, normalized segmentation mean value. CNV, Copy number variation. SNP, Single nucleotide polymorphism. Gain, copy gain variations in HCC tissues. Loss, copy loss variations in HCC tissues. Down, down-regulated in HCC tissues; Up, up-regulated in HCC tissues. *P < 0.05, **P < 0.01, ***P < 0.001