Fig. 3

EccDNA frequency relative to chromosome and gene density. A All eccDNAs per Mb from control (blue dot) and DCM (red triangle) groups per chromosome. B The number of eccDNAs with protein-coding genes is quantified and categorized by chromosome in control (blue box) and DCM (red box) samples. C The number of eccDNAs without protein-coding genes is quantified and categorized by chromosome in control (blue box) and DCM (red box) samples. D All eccDNAs per Mb from control (blue dot) and DCM (red triangle) groups per protein-coding genes per Mb (chromosome 17 and 19 are marked). E EccDNAs with protein-coding genes per protein coding genes per Mb (chromosome 17 and 19 are marked). F EccDNAs without protein-coding genes per protein coding genes per Mb