Fig. 1
From: Telomeres: an organized string linking plants and mammals
Telomeres organization in mammals: (A) Human and (B) mouse shelterin shares a similar composition and organization, with six-proteins forming the complex (TRF1, TRF2, TIN2, TPP1, RAP1 and POT1) that binds to telomeric 5’-TTAGGG-3’ repetitions. Unlike humans, mouse shelterin is composed of two POT1 proteins. (C-D) Mammalian shelterins are composed of proteins containing a Myb-domain (TRFs) that bind telomeric dsDNA, and containing OBs-folds (POT1), that bind telomeric ssDNA. (E) Human telomerase is composed of an enzymatic (TERT) and an RNA-template (TR) subunits. Mammalian telomeres possess both euchromatic and heterochromatic epigenetic marks