Table 1 List of regulators of telomere metabolism in Arabidopis, mice and humans

Chromatin mark (-)

H3K9me2

H3K9me3

H3K9me3

[1, 2]

–

H4K20me3

H4K20me3

[3, 4]

H3K27me3

–

H3K27me3

[1, 5]

Chromatin mark ( +)

H3K4me2

–

–

[6]

H3K4me3

H3K4me3

H3K4me3

[2, 7]

–

H4K20me1

H4K20me1

[2]

H3K9ac

H3K9ac

H3K9ac

[6-8]

–

H3K27ac

H3K27ac

[2]

Overhang

5'-TTTAGGG-3'

5'-TTAGGG-3'

5'-TTAGGG-3'

[9, 10]

2,5-5 kb

 ~ 50 kb

5-15 kb

[11, 12]

Overhang binding proteins

STN1

STN1

STN1

[8]

TEN1

TEN1

TEN1

CTC1

CTC1

CTC1

Shelterin

TRB1, 2, 3

TRF1

TRF1

[10, 13]

–

TRF2

TRF2

[10]

POT1 a, b, c

POT1a/b

POT1

[10], [14–16]

–

TIN2

TIN2

[10]

–

TPP1

TPP1

–

RAP1

RAP1

Telomerase composition

TERT

TERT

TERT

[96], [17–20]

TER

TR

TR

CBF5

Dyskerin

Dyskerin

NHP2

NHP2

NHP2

NOP10

NOP10

NOP10

GAR1

GAR1

GAR1

NAF1

–

–

RuvBLs

Pontin/Reptin

Pontin/Reptin

–

Hsp90

Hsp90

–

p23

p23

TRBs

–

–

POT1a

–

–

Telomerase expression

Pollen, seedling, young rosette leaves, siliques, SAM, RAM

Embryo, brain, thymus, hearth, lung, liver, spleen, kidney, intestine, muscle, skin, testis

Blastocyst, fetuses (no brain), hair follicle bulbs, basal cells of the gastrointestinal tract, basal keratinocytes of the skin lymphocytes, hematopoietic progenitors, stem cells, urothelium, prostate, endometrium, cancer cells

[21–32]