Fig. 4

20-gene TMB and DNAH5 mutation prognostic role. (a) Kaplan–Meier curves showing the effect of 20-gene TMB on OS in the combined CRC cohort. (b) The effect of 20-gene TMB on PFS in the combined CRC cohort. (c) Density plots of the TMB high-sample and TMB low-sample distributions and the corresponding cut points. (d) Forest plot summarizing prognostic impact of 20-gene TMB on OS by multivariable Cox regression. (e) Forest plot summarizing prognostic impact of 20-gene TMB on PFS by multivariable Cox regression. (f) The forest plot shows the results of multivariable Cox regression in patients with high TMB. (g) OS in groups TMB^low, TMB^high DNAH5^wild and TMB^high DNAH5^mut. (h) PFS in groups TMB^low, TMB^high DNAH5^wild and TMB^high DNAH5^mut