Fig. 5
Clinical and gene expression features of patients with TMBhigh DNAH5mut. (a) The bar graphs show the proportions of MSS and MSI in different subgroups of patients with CRC. p = 0.535, Chi-square test. (b) Box plots of DNA damage response and DNA repair pathway signature scores. (c) Top 10 (ordered by false discovery rate [FDR] < 0.05) significantly enriched GO terms (gene ontology biological process) derived from genes highly expressed in patients with high TMB. (d) Among patients with high-TMB, top-10 significantly enriched GO terms derived from genes highly expressed in patients with DNAH5 mutations. (e) Box plots showing the TME and immune cell infiltration scores. (f) Box plots of immunotherapy signature scores. (g) Box plots of the scores for the antigen presentation related signatures. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001, 1-way ANOVA was used to determine significance of differences between the three groups