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Fig. 3 | Biology Direct

Fig. 3

From: Exosomes containing circSCP2 in colorectal cancer promote metastasis via sponging miR-92a-1-5p and interacting with PTBP1 to stabilize IGF2BP1

Fig. 3

knockdown of circSCP2 inhibited the growth and metastasis of RKO cells in vivo. (A) Tumor size and (B) growth of the subcutaneous tumor growth model injected with RKO cells (n = 10 mice/group). (C) Representative images and (D) relative HE staining of lung metastasis of mice using luciferase-based bioluminescence imaging. (E) IHC analysis of N-cadherin and Vimentin in lung metastasis of mice (n = 4 mice/group). (F) Quantitative analysis of lung metastases and luminescence in the lung metastasis mice models. (G) Representative images and (H) relative HE staining of liver metastasis of mice using luciferase-based bioluminescence imaging. (I) IHC analysis of N-cadherin and Vimentin in liver metastasis of mice. (J) Quantitative analysis of liver metastases and luminescence in the liver metastasis mice models (n = 4 mice/group). Scale bar, 400 μm. The results were presented as the means ± SD. Data were compared using Student’s t-tests

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