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Fig. 8 | Biology Direct

Fig. 8

From: Exosomes containing circSCP2 in colorectal cancer promote metastasis via sponging miR-92a-1-5p and interacting with PTBP1 to stabilize IGF2BP1

Fig. 8

Schematic representation of the role of exosomal circSCP2 in CRC progression and metastasis. The schematic shows the effect of circSCP2 on CRC cells through sponging miR-92a-1-5p and also suppressing PTBP1 degradation, and subsequently promote EMT, tumor migration and invasion via upregulation of downstream IGF2BP1 mRNA and protein expression. Moreover, exosomal circSCP2 released by CRC tumors could either transform normal fibroblasts into activated carcinoma-associated fibroblasts, or transform macrophages into M2 tumor-associated macrophages, which further form positive feedback loops to accelerate tumor progression, invasion, migration and immunosuppression

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Biology Direct

ISSN: 1745-6150

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