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Fig. 9 | Biology Direct

Fig. 9

From: MLL1 promotes placental trophoblast ferroptosis and aggravates preeclampsia symptoms through epigenetic regulation of RBM15/TRIM72/ADAM9 axis

Fig. 9

MLL1 promotes RBM15 expression by increasing H3K4me3 on the RBM15 promoter; RBM15 upregulates TRIM72 mRNA m6A modification, promotes the binding between YTHDF2 and TRIM72, and then degrades TRIM72 mRNA and inhibits TRIM72 expression, thereby reducing the ubiquitination degradation of ADAM9, stabilizing the expression of ADAM9, and eventually promoting ferroptosis of trophoblasts and aggravating PE

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Biology Direct

ISSN: 1745-6150

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