Fig. 2

Single-cell transcriptional profiling of epithelial cells and the GO analysis of DEGs. A. UMAP plots of the epithelial cells. B. Relative proportion of epithelial cells subsets in ER and ENR group. C. The heatmap of differentially expressed genes in secretory cells between ER and ENR. D. The GO analysis of down-regulated DEGs shows top10 highlighted pathways in secretory cells of the ER group (n = 10, hypergeometric test, adjusted p-values obtained by Benjamini-Hochberg procedure). E. The GO analysis of up-regulated DEGs shows top10 highlighted pathways in secretory cells of the ER group