Fig. 3

The fibroblasts cell markers and trajectory branch. A. UMAP plots of the fibroblasts. B. The heatmap of clustered top DEGs across seven groups of fibroblasts. C. Proportion of fibroblasts subsets in ER and ENR group. D. The KEGG analysis of up-regulated DEGs shows mostly highlighted pathways in fibroblasts2 cluster. E. The GO analysis of up-regulated DEGs shows top10 highlighted terms in fibroblasts1 cluster. F. Pseudo-time trajectories developed through Monocle2 analysis for fibroblasts