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Fig. 1 | Biology Direct

Fig. 1

From: TFAP2C-mediated transcriptional activation of STEAP3 promotes lung squamous cell carcinoma progression by regulating the β-catenin pathway

Fig. 1

STEAP3 is highly expressed in lung squamous cell carcinoma (LUSC) tissues. (A) The mRNA levels of STEAP3 in LUSC and adjacent normal tissues were analyzed using the TCGA database. (B) A total of 40 paired LUSC and adjacent normal lung tissues were collected for mRNA level analysis of STEAP3. GAPDH was employed as the internal control. (C) The protein levels of STEAP3 in LUSC and adjacent normal tissues were analyzed by immunohistochemistry. Scale bar represents 100 μm. (D) The mRNA levels of STEAP3 in four human LUSC cell lines, including NCI-H1703, SK-MES-1, NCI-H520, and NCI-H226, as well as normal bronchial epithelial cells (BEAS-2B), were determined by real-time PCR analysis. GAPDH was employed as the internal control. (E) The protein levels of STEAP3 in four human LUSC cell lines and BEAS-2B were determined by western blot analysis. β-actin was employed as the internal control. (F) The Kaplan-Meier Plotter database was employed to compare overall survival (OS) and recurrence-free survival (RFS) between groups with disparate STEAP3 expression levels. *P < 0.05 and **P < 0.01

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Biology Direct

ISSN: 1745-6150

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