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Fig. 3 | Biology Direct

Fig. 3

From: TFAP2C-mediated transcriptional activation of STEAP3 promotes lung squamous cell carcinoma progression by regulating the β-catenin pathway

Fig. 3

Knockdown of STEAP3 inhibits the EMT and the β-catenin signaling pathway in LUSC cells. (A) Following the knockdown and overexpression of STEAP3, the cells were subjected to immunofluorescence analysis of the expression levels of E-cadherin and N-cadherin. Scale bar represents 50 μm. (B) Total proteins were extracted from the stable transfectants and then the protein levels of Vimentin and Slug were quantified by western blot analysis. β-actin was employed as the internal control. (C) The protein levels of β-catenin in the cytoplasm and nucleus were quantified by western blot analysis. β-actin was employed as the internal control. (D) The protein levels of c-myc and cyclin D1 were quantified by western blot analysis. β-actin was employed as the internal control. *P < 0.05 and **P < 0.01

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Biology Direct

ISSN: 1745-6150

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