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Fig. 4 | Biology Direct

Fig. 4

From: Enhanced itaconic acid secretion from macrophages mediates the protection of mesenchymal stem cell-derived exosomes on lipopolysaccharide-induced acute lung injury mice

Fig. 4

MSC-exos attenuate LPS-induced acute lung injury in mice by enhancing ITA secretion. C57BL/6 wild-type and IRG1 knockout (Irg1−/−) mice were used to investigate the protective effects of MSC-exos in vivo. After mice were treated with MSC-exos, (A) lung tissues were collected and received H&E staining. (B) Additionally, ITA concentrations were observed in plasma. (C) lung injury scores were calculated according to alveolar edema, hemorrhage, alveolar septal thickening and polymorphonuclear leukocyte infiltration. (D) The wet-to-dry weight ratio of the lungs indicated the severity of pulmonary edema. Bronchoalveolar lavage fluid were collected to determine (E) total protein levels and (F) neutrophil counts. Data are presented as mean ± SEM, with *p < 0.05, ***p < 0.001. ITA: itaconic acid; MSC-exos: mesenchymal stem cell-derived exosome

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