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Fig. 5 | Biology Direct

Fig. 5

From: Enhanced itaconic acid secretion from macrophages mediates the protection of mesenchymal stem cell-derived exosomes on lipopolysaccharide-induced acute lung injury mice

Fig. 5

MSC-exos suppress LPS-induced inflammation in acute lung injury mice by regulating alveolar macrophage polarization. After treatment of MSC-exos, the levels of (A) IL-6 and (B) TNF-α were assessed in bronchoalveolar lavage fluid of wild-type and Irg1−/− mice. (C) iNOS and Arg-1 protein levels were detected by the western blot analysis to assess M1 polarization. (D) M2 polarization was determined based on CD206-positive cells via flow cytometry analysis. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, and ***p < 0.001. MSC-exos: mesenchymal stem cell-derived exosome

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