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Fig. 2 | Biology Direct

Fig. 2

From: Boanmycin overcomes bortezomib resistance by inducing DNA damage and endoplasmic reticulum functional impairment in multiple myeloma

Fig. 2

Boanmycin enhances the inhibitory effect of BTZ in multiple myeloma cells. (A) The relative viability of U266B1 and MM.1 S cells treated with different concentrations of BTZ and boanmycin for 48 h was determined. (B) Western blot analysis was conducted on PARP, cleaved PARP, cleaved caspase 3 and cleaved caspase 7 proteins after the cells were treated with BTZ and/or boanmycin for 48 h. α-Tubulin was used as a control. (C) Apoptosis analysis was performed via flow cytometry using Annexin V/PI staining. (mean ± SD, *p < 0.05, **p < 0.01 and ***p < 0.001)

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Biology Direct

ISSN: 1745-6150

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